LC-MS/MS metabolomics unravels the resistant phenotype of carbapenemase-producing Enterobacterales.

Journal: Metabolomics : Official journal of the Metabolomic Society
Published Date: Aug 12, 2025

Abstract

INTRODUCTION: The degree of antimicrobial resistance demonstrated by carbapenemase-producing Enterobacterales (CPE) represents a growing public health challenge. Conventional methods for detecting CPE involve culture-based techniques with lengthy incubation steps. There is a need to develop rapid and accurate methods for the detection of resistance, for implementation into clinical diagnostics.

Authors

  • Breanna Dixon
    Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Waqar M Ahmed
    Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Stephen J Fowler
    Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Tim Felton
    Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Drupad K Trivedi
    Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, Manchester, UK. drupad.trivedi@manchester.ac.uk.

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