Altered theta oscillations in basolateral amygdala and ventral hippocampus related to social defeat.

Journal: BMC neuroscience
Published Date: Aug 27, 2025

Abstract

BACKGROUND: Depression is a prevalent mental disorder, and prolonged exposure to social defeat is a major contributing factor in the onset of depression. Repeated social defeat stress (RSDS) is a commonly used animal model for depression, significantly impacting on the pathogenesis of depression-related to social disorders. The basolateral amygdala (BLA) and the ventral hippocampus (vHPC) are critical brain regions involved in RSDS-induced social behavioral disorders, but the specific neural oscillations occurring in these regions following social defeat remain unclear.

Authors

  • Xinyu Wang
    Department of Endocrinology, Institute of Translational Medicine, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
  • Yinglong Liu
    United Imaging Research Institute of Innovative Medical Equipment, Shenzhen, China.
  • Fengkai He
    School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
  • Dongyong Guo
    Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Aili Liu
    School of Basic Medicine, Tianjin Medical University, Tianjin, 300070, China.
  • Wenwen Bai
    School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
  • Huiyun Yang
    School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
  • Xinyu Xu
    School of Computer Science and Technology, Xidian University, Xi'an 710071, China.
  • Xuyuan Zheng
    School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China.
  • Xiaojun Xu
    Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Joint Laboratory of Clinical Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • TiaoTiao Liu
    School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China. liutt@tmu.edu.cn.

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