Label-free diagnostic procedure for hirschsprung's disease to detect intestinal mucosal characteristics of aganglionosis by Raman spectroscopy with optimized decision algorithms.

Journal: Lasers in medical science
Published Date: Aug 29, 2025

Abstract

PURPOSE: Hirschsprung's disease (HSCR) is an intestinal disorder characterized by the absence of nerve cells in parts of the intestinal tract. The definitive diagnosis is confirmed by a full-thickness rectal biopsy to verify the absence of ganglion cells. However, incomplete removal often causes post-operative complications. To establish an optical biopsy technique for targeting mucosa with aganglionosis of HSCR and to confirm its capability by another optical imaging modality and histopathology.

Authors

  • Yusuke Oshima
    Faculty of Engineering, University of Toyama, Toyama, Japan. oshima@eng.u-toyama.ac.jp.
  • Yuki Matsumoto
    Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
  • Katsuhiro Ogawa
    Department of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Yufu, Japan.
  • Kai Tamura
    Graduate School of Pharma-Medical Sciences, University of Toyama, Toyama, Japan.
  • Rena Yagi
    Department of Intellectual Information Engineering, School of Engineering, Toyama, Japan.
  • Noritaka Fujisawa
    Graduate School of Science and Engineering, University of Toyama, Toyama, Japan.
  • Takashi Katagiri
    Faculty of Engineering, University of Toyama, Toyama, Japan.
  • Shun Onishi
    Department of Pediatric Surgery, Medical and Dental Area, Research and Education Assembly, Research Field in Medical and Health Sciences, Kagoshima University, Kagoshima, Japan.
  • Hidefumi Shiroshita
    Department of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Oita, Japan.
  • Tsuyoshi Etho
    Department of Gastroenterological and Pediatric Surgery, Faculty of Medicine, Oita University, Yufu, Japan.
  • Tsutomu Daa
    Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Satoshi Ieiri
    Department of Advanced Medicine and Innovative Technology, Kyushu University Hospital, Fukuoka, Japan.
  • Masafumi Inomata
    Faculty of Medicine, Department of Gastroenterological and Pediatric Surgery, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-City, Oita, 879-5593, Japan.

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