Achyranthes Bidentata Radix mitigates neuronal apoptosis via regulation of JUN and CREB in the cAMP signaling pathway.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology

Published Date: Jul 5, 2025

BACKGROUND: Although Achyranthes Bidentata Radix (ABR) demonstrates neuroprotective potential in NDDs, its anti-apoptotic mechanisms remain unclear.

Yan Liu

Department of Clinical Microbiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, People's Republic of China.
Ai-Bing Chang

Shaanxi University of Chinese Medicine, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Xianyang 712083, China.
Yan-Ru Liu

Shaanxi University of Chinese Medicine, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Xianyang 712083, China. Electronic address: yanzi_2203@aliyun.com.
Zhi-shu Tang
Zhong-Xing Song

Shaanxi University of Chinese Medicine, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Xianyang 712083, China.
Xiu-He Fan

Shaanxi University of Chinese Medicine, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Xianyang 712083, China.
Mi Zhou

The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangzhou, China.
Xing-Chi Wang

Shaanxi University of Chinese Medicine, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Xianyang 712083, China.

Achyranthes Animals Apoptosis Cell Line Cyclic AMP Cyclic AMP Response Element-Binding Protein Mice Neurons Neuroprotective Agents Plant Roots Proto-Oncogene Proteins c-jun Signal Transduction Zebrafish

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