Achyranthes

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Achyranthes Bidentata Radix mitigates neuronal apoptosis via regulation of JUN and CREB in the cAMP signaling pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology Jul 5, 2025
BACKGROUND: Although Achyranthes Bidentata Radix (ABR) demonstrates neuroprotective potential in NDDs, its anti-apoptotic mechanisms remain unclear.
Animals Mice Signal Transduction Neuroprotective Agents Apoptosis Cell Line Plant Roots Cyclic AMP Response Element-Binding Protein Neurons Zebrafish Cyclic AMP Achyranthes Proto-Oncogene Proteins c-jun
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Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro.

The Kaohsiung journal of medical sciences Dec 30, 2016
Achyranthes bidentate Blume (Niuxi) is often employed for treatment of arthritis in Traditional Chinese Medicine and possesses anti-inflammatory properties. Phytochemical and pharmacological studies proved the oleanane-type saponins to be the main bi...
Animals Male Plant Extracts Rats Inflammation Signal Transduction Rats, Sprague-Dawley Apoptosis Caspase 3 Anti-Inflammatory Agents, Non-Steroidal Plant Roots Interleukin-1beta NF-kappa B Matrix Metalloproteinase 9 bcl-2-Associated X Protein Chondrocytes Saponins Tumor Suppressor Protein p53 Gene Expression Regulation Proliferating Cell Nuclear Antigen Cyclooxygenase 2 Cartilage, Articular Matrix Metalloproteinase 3 Primary Cell Culture Achyranthes bcl-Associated Death Protein bcl-X Protein
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