AIMC Topic: Cyclic AMP

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A potential supplemental indication of dipyridamole for contraception: Dipyridamole inhibits mouse sperm fertilization capacity in vitro.

Biochemical and biophysical research communications Apr 11, 2025
The inhibition of sperm cAMP and ATP levels, using an FDA-approved medication, may impair sperm motility and, consequently, fertilization, thus paving the way for the development of a male contraceptive. The objective of this study was to define the ...
Female Animals Male Mice Fertilization in Vitro Spermatozoa Sperm Motility Adenosine Triphosphate Cyclic AMP Fertilization Dipyridamole Contraceptive Agents, Male Contraception
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Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-B/p65 Signaling in Chronic Radiculitis Rats.

Pain research & management Dec 13, 2018
BACKGROUND: Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate ch...
Animals Male Rats, Wistar Rats Signal Transduction Treatment Outcome Disease Models, Animal Oxygen Ozone NF-kappa B Radiculopathy Intervertebral Disc Displacement Cyclic AMP Cyclic GMP Cyclic Nucleotide Phosphodiesterases, Type 2 Hyperalgesia Transcription Factor RelA
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