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Cyclic AMP

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Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-B/p65 Signaling in Chronic Radiculitis Rats.

Pain research & management
BACKGROUND: Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate ch...

A potential supplemental indication of dipyridamole for contraception: Dipyridamole inhibits mouse sperm fertilization capacity in vitro.

Biochemical and biophysical research communications
The inhibition of sperm cAMP and ATP levels, using an FDA-approved medication, may impair sperm motility and, consequently, fertilization, thus paving the way for the development of a male contraceptive. The objective of this study was to define the ...