Explainable classification of Parkinson's disease with different motor subtypes by analyzing the synthetic MRI quantitative parameters of subcortical nuclei.

Journal: European journal of radiology
Published Date:

Abstract

OBJECTIVES: To explore differences in quantitative parameters of subcortical nuclei using synthetic MRI across different motor subtypes of Parkinson's Disease (PD), and to develop an interpretable model for distinguishing PD subtypes.

Authors

  • Dongliang Cheng
    Hebin Intelligent Robots Co., LTD, Hefei, Anhui Province, China.
  • Junyan Wen
    Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Yulin Liu
    Department of Radiology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Nan Ding
    Reproductive Medicine Center, Lanzhou University Second Hospital, No.82, Cuiying Road, Chengguan District, Lanzhou City, Gansu Province, China.
  • Zhenpeng Duan
    Department of Neurology, The First People's Hospital of Foshan, Foshan, China.
  • Yunjun Yang
    Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. yyjunjim@163.com.
  • Yaozhong Wu
    Department of Radiology, The First People's Hospital of Foshan, Foshan, China.
  • Hang Wang
    Key Subject Laboratory of Nuclear Safety and Simulation Technology, Harbin Engineering University, Harbin, 150001, China. Electronic address: wanghang1990312@126.com.
  • Jincheng Ma
    Department of Radiology, The First People's Hospital of Foshan, Foshan, China.
  • Jialu Zhang
    GE Healthcare, MR Research, Beijing, China.
  • Zhifeng Xu
    College of Plant Protection, Southwest University, Chongqing, China.
  • Hai Zhao
  • Ge Wen
    Medical Imaging Center, Nanfang Hospital, Southern Medical University, 1023 Shatai South Road, Baiyun District, Guangzhou, Guangdong, China. m13360022166@163.com.