Artificial intelligence-quantified schisis volume as a structural endpoint for gene therapy clinical trials in X-linked retinoschisis.

Journal: Acta ophthalmologica
Published Date:

Abstract

PURPOSE: To use artificial intelligence (AI) for quantifying schisis volume (ASV) in X-linked retinoschisis (XLRS) for use as a structural endpoint in gene therapy clinical trials.

Authors

  • Tien-En Tan
    Singapore Eye Research Institute, Singapore National Eye Centre.
  • Peilun Dai
    Institute of High Performance Computing, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
  • Jonathan Hensman
    Department of Ophthalmology, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
  • Peter Kiraly
    Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Beau J Fenner
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
  • Yong Liu
    Department of Critical care medicine, Shenzhen Hospital, Southern Medical University, Guangdong, Shenzhen, China.
  • Rick S M Goh
    Institute of High Performance Computing, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Ian C Han
    The University of Iowa Institute for Vision Research, The University of Iowa, Iowa City, Iowa, USA.
  • Daniel S W Ting
    Singapore National Eye Center, Duke-National University of Singapore Medical School, Singapore 168751, Singapore; National Institutes of Health Research Biomedical Research Centre Biomedical Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK. Electronic address: daniel.ting.s.w@singhealth.com.sg.
  • Camiel J F Boon
    Department of Ophthalmology, Leiden University Medical Center, P. O. Box 9600, 2300 RC, Leiden, The Netherlands. cjfboon@hotmail.com.
  • M Dominik Fischer
    Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.