Cell-free DNA in ex-vivo lung perfusate is associated with low-quality lungs and lung transplant outcome.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Published Date:

Abstract

BACKGROUND: Cell-free DNA (cfDNA) in ex-vivo lung perfusion (EVLP) perfusate has been shown to potentially reflect lung injury; however, the relationship between cfDNA concentration with clinical EVLP lung outcomes has not been elucidated.

Authors

  • Haruchika Yamamoto
    Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Department of General Thoracic Surgery, Okayama University Hospital, Okayama, Japan.
  • Gavin W Wilson
    Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Adam Sundby
    Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Siyi Zhu
    Department of Computer Science, Xiamen University, Xiamen 361005, China.
  • Jonathan Allen
    Lawrence Livermore National Laboratory, Livermore, CA, United States of America.
  • Bonnie T Chao
    Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Akhi Akhter
    Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Shaf Keshavjee
    Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
  • Andrew Sage
    Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Jonathan C Yeung
    Toronto Lung Transplant Program and Latner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada. Electronic address: jonathan.yeung@uhn.ca.