BACKGROUND: Protein lactylation has been implicated in stress-responsive cellular mechanisms, yet its role in lung transplantation-associated ischemia-reperfusion injury (IRI) remains undefined.
Transplantation of donor grafts recellularized with recipient-derived or non-immunogenic universal cells is a potential means of reducing the graft rejection and post-transplant complications in lung transplantation. Achieving a fully recellularized ...
Current opinion in pulmonary medicine
Apr 21, 2025
PURPOSE OF REVIEW: To explore the current applications of artificial intelligence and machine learning in lung transplantation, including outcome prediction, drug dosing, and the potential future uses and risks as the technology continues to evolve.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Mar 4, 2025
BACKGROUND: Cell-free DNA (cfDNA) in ex-vivo lung perfusion (EVLP) perfusate has been shown to potentially reflect lung injury; however, the relationship between cfDNA concentration with clinical EVLP lung outcomes has not been elucidated.
BACKGROUND: An ideal lung allocation system should reduce waiting list deaths, improve transplant survival, and ensure equitable organ allocation. This study aimed to develop a novel lung allocation score (LAS) system, the MaxBenefit LAS, to maximize...
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Feb 7, 2025
Primary graft dysfunction (PGD) is a common complication after lung transplantation associated with poor outcomes. Although risk factors have been identified, the complex interactions between clinical variables affecting PGD risk are not well underst...
BACKGROUND: Primary graft dysfunction (PGD) develops within 72 h after lung transplantation (Lung Tx) and greatly influences patients' prognosis. This study aimed to establish an accurate machine learning (ML) model for predicting grade 3 PGD (PGD3) ...
BACKGROUND: Ex vivo lung perfusion (EVLP) is a critical strategy to rehabilitate marginal donor lungs, thereby increasing lung transplantation (LTx) rates. Ischemia-reperfusion (I/R) injury inevitably occurs during LTx. Exploring the common mechanism...
We aimed to evaluate the image quality and diagnostic performance of chronic lung allograft dysfunction (CLAD) with lung ventilation single-photon emission computed tomography (SPECT) images acquired briefly using a convolutional neural network (CNN)...
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Aug 23, 2024
Lung size measurements play an important role in transplantation, as optimal donor-recipient size matching is necessary to ensure the best possible outcome. Although several strategies for size matching are currently used, all have limitations, and n...
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