Automated radiosynthesis of [(18)F]ciprofloxacin.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Published Date: Feb 27, 2015

Abstract

We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing the standard 15-mL glassy carbon reactor of the synthesis module with a 3-mL V-shaped borosilicate glass reactor a considerable improvement in RCY was observed. [(18)F]Ciprofloxacin was obtained in a RCY of 2.7±1.4% (n=23) with a specific activity at EOS of 1.4±0.5GBq/µmol in a synthesis time of 160min.

Authors

  • Johann Stanek
    Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Währiger-Gürtel 18-20, A-1090 Vienna, Austria.
  • Severin Mairinger
    Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria.
  • Thomas Wanek
    Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria.
  • Claudia Kuntner
    Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria.
  • Markus Müller
    Department of Clinical Pharmacology, Medical University of Vienna, Währiger-Gürtel 18-20, A-1090 Vienna, Austria.
  • Oliver Langer
    Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Währiger-Gürtel 18-20, A-1090 Vienna, Austria. Electronic address: oliver.langer@ait.ac.at.

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