AIMC Topic: Isotope Labeling

Clear Filters Showing 1 to 6 of 6 articles

A robust multiplex-DIA workflow profiles protein turnover regulations associated with cisplatin resistance and aneuploidy.

Nature communications May 30, 2025
Quantifying protein turnover is fundamental to understanding cellular processes and advancing drug discovery. Multiplex-DIA mass spectrometry (MS), combined with dynamic SILAC labeling (pulse-SILAC, or pSILAC) reliably measures protein turnover and d...
Workflow Cisplatin Proteome Mass Spectrometry Drug Resistance, Neoplasm Humans Proteolysis Isotope Labeling Cell Line, Tumor Mitochondria Proteomics Aneuploidy Machine Learning
View on PubMed DOI

Quantitation of anacetrapib, stable-isotope labeled-anacetrapib (microdose), and four metabolites in human plasma using liquid chromatography tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Dec 29, 2015
An ultra-high performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous determination of (4S,5R)-5-[3,5-bis (trifluoromethyl)phenyl]-3-{[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl] met...
Isotope Labeling Tandem Mass Spectrometry Biological Availability Sensitivity and Specificity Humans Linear Models Chromatography, Liquid Reproducibility of Results Oxazolidinones
View on PubMed DOI

Machine Learning-based Classification of Diffuse Large B-cell Lymphoma Patients by Their Protein Expression Profiles.

Molecular & cellular proteomics : MCP Aug 26, 2015
Characterization of tumors at the molecular level has improved our knowledge of cancer causation and progression. Proteomic analysis of their signaling pathways promises to enhance our understanding of cancer aberrations at the functional level, but ...
Proteome Signal Transduction Gene Expression Regulation, Neoplastic Proteomics Formaldehyde Apoptosis Regulatory Proteins Isotope Labeling Neoplasm Proteins Principal Component Analysis Machine Learning Biomarkers, Tumor Lymphoma, Large B-Cell, Diffuse Cell Line, Tumor Humans Tissue Fixation Phosphoprotein Phosphatases GTPase-Activating Proteins Tissue Embedding Neprilysin
View on PubMed DOI

Automated electrophilic radiosynthesis of [¹⁸F]FBPA using a modified nucleophilic GE TRACERlab FXFDG.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Jul 2, 2015
We modified a commercially available synthesis module for nucleophilic [(18)F]fluorinations (TRACERlab(TM) FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[(18)F]fluoro-4-borono-L-phenylalanine ([(18)F]FBPA) via direct electrophilic subst...
Boron Compounds Electron Transport Isotope Labeling Electrons Materials Testing Phenylalanine Equipment Failure Analysis Fluorine Radioisotopes Equipment Design Radiopharmaceuticals Robotics
View on PubMed DOI

Fully-automated synthesis of 16β-(18)F-fluoro-5α-dihydrotestosterone (FDHT) on the ELIXYS radiosynthesizer.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine May 21, 2015
Noninvasive in vivo imaging of androgen receptor (AR) levels with positron emission tomography (PET) is becoming the primary tool in prostate cancer detection and staging. Of the potential (18)F-labeled PET tracers, (18)F-FDHT has clinically shown to...
Radionuclide Generators Drug Design Fluorine Radioisotopes Specimen Handling Dihydrotestosterone Radiopharmaceuticals Robotics Isotope Labeling Equipment Failure Analysis Rheology Equipment Design
View on PubMed DOI

Automated radiosynthesis of [(18)F]ciprofloxacin.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Feb 27, 2015
We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing th...
Equipment Design Ciprofloxacin Robotics Equipment Failure Analysis Isotope Labeling Radiopharmaceuticals Fluorine Radioisotopes
View on PubMed DOI
Popular Topics
Recent Journals