Unveiling the intricate interplay: Exploring biological bridges between renal ischemia-reperfusion injury and T cell-mediated immune rejection in kidney transplantation.

Journal: PloS one
PMID: 39715172

Abstract

UNLABELLED: Although the link between ischemia-reperfusion injury (IRI) and T cell-mediated rejection (TCMR) in kidney transplantation (KT) is well known, the mechanism remains unclear. We investigated essential genes and biological processes involved in interactions between IRI and TCMR.

Authors

  • Xinyi Xia
    Department of Cardiology, Union Hospital, Huazhong University of Science and Technology and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Tongji Medical College, Wuhan, China.
  • Xinrui Fan
    Faculty of Psychology, Sleep and NeuroImaging Center, Southwest University, Chongqing, China.
  • Shan Jiang
    Emergency Center, Hubei Clinical Research Center for Emergency and Resuscitaion, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Yuhan Liao
    Department of Cardiology, Union Hospital, Huazhong University of Science and Technology and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Tongji Medical College, Wuhan, China.
  • Yang Sun
    Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

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