AIMC Topic: Lectins, C-Type

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Cancer-associated fibroblasts enhance colorectal cancer lymphatic metastasis via CLEC11A/LGR5-mediated WNT pathway activation.

The Journal of clinical investigation Oct 15, 2025
Hypoxia in the tumor microenvironment promotes lymphatic metastasis, yet the role of cancer-associated fibroblasts (CAFs) in this process remains insufficiently elucidated in colorectal cancer (CRC). In this study, we developed a large language model...
Humans Female Colorectal Neoplasms Animals Male Cell Line, Tumor Mice Lymphatic Metastasis Mice, Nude Cancer-Associated Fibroblasts Receptors, G-Protein-Coupled Neoplasm Proteins Lectins, C-Type Wnt Signaling Pathway
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Unveiling the intricate interplay: Exploring biological bridges between renal ischemia-reperfusion injury and T cell-mediated immune rejection in kidney transplantation.

PloS one Dec 23, 2024
UNLABELLED: Although the link between ischemia-reperfusion injury (IRI) and T cell-mediated rejection (TCMR) in kidney transplantation (KT) is well known, the mechanism remains unclear. We investigated essential genes and biological processes involve...
Humans Kidney Transplantation T-Lymphocytes Gene Expression Profiling Gene Regulatory Networks Kidney MicroRNAs Reperfusion Injury Graft Rejection Antigens, Differentiation, T-Lymphocyte Lectins, C-Type Antigens, CD
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A Machine Learning Approach to Identify C Type Lectin Domain (CTLD) Containing Proteins.

The protein journal Jul 28, 2024
Lectins are sugar interacting proteins which bind specific glycans reversibly and have ubiquitous presence in all forms of life. They have diverse biological functions such as cell signaling, molecular recognition, etc. C-type lectins (CTL) are a gro...
Humans Machine Learning Lectins, C-Type Protein Domains
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