Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism.

Journal: BMC bioinformatics

PMID: 26047810

Abstract

BACKGROUND: People with an autistic spectrum disorder (ASD) display a variety of characteristic behavioral traits, including impaired social interaction, communication difficulties and repetitive behavior. This complex neurodevelopment disorder is known to be associated with a combination of genetic and environmental factors. Neurexins and neuroligins play a key role in synaptogenesis and neurexin-neuroligin adhesion is one of several processes that have been implicated in autism spectrum disorders.

Authors

Sejal Patel

Institute of Medical Science, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, M5S 1A8, Canada. sejalr.patel@mail.utoronto.ca.
Paola Roncaglia

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. paola@ebi.ac.uk.
Ruth C Lovering

Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, Rayne Building, 5 University Street, London, WC1E 6JF, UK. r.lovering@ucl.ac.uk.

Keywords

Animals Autistic Disorder Calcium-Binding Proteins Cell Adhesion Molecules, Neuronal Cell Physiological Phenomena Gene Ontology Genome Genomics High-Throughput Nucleotide Sequencing Humans Membrane Potentials Mice Models, Molecular Nerve Tissue Proteins Neural Cell Adhesion Molecules Phenotype Rats Social Behavior Synapses Synaptic Potentials

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View on PubMed Access via DOI PubMed (26047810)

Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism.

Abstract

Authors

Keywords

External Resources

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