A machine learning approach to identify functional biomarkers in human prefrontal cortex for individuals with traumatic brain injury using functional near-infrared spectroscopy.

Journal: Brain and behavior
Published Date: Nov 1, 2016

Abstract

BACKGROUND: We have explored the potential prefrontal hemodynamic biomarkers to characterize subjects with Traumatic Brain Injury (TBI) by employing the multivariate machine learning approach and introducing a novel task-related hemodynamic response detection followed by a heuristic search for optimum set of hemodynamic features. To achieve this goal, the hemodynamic response from a group of 31 healthy controls and 30 chronic TBI subjects were recorded as they performed a complexity task.

Authors

  • Nader Karamzadeh
    Department of Computational and Data Sciences George Mason University Fairfax VA USA; National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA.
  • Franck Amyot
    Department of Neurology Center for Neuroscience and Regenerative Medicine Uniformed Services Bethesda MD USA.
  • Kimbra Kenney
    Department of Neurology Center for Neuroscience and Regenerative Medicine Uniformed Services Bethesda MD USA.
  • Afrouz Anderson
    National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA.
  • Fatima Chowdhry
    National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA.
  • Hadis Dashtestani
    National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA.
  • Eric M Wassermann
    National Institute of Mental Health National Institutes of Healthy Bethesda MD USA.
  • Victor Chernomordik
    National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA.
  • Claude Boccara
    Institut Langevin ESPCI-ParisTech Paris France.
  • Edward Wegman
    Department of Computational and Data Sciences George Mason University Fairfax VA USA.
  • Ramon Diaz-Arrastia
    Department of Neurology Center for Neuroscience and Regenerative Medicine Uniformed Services Bethesda MD USA.
  • Amir H Gandjbakhche
    National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA.

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