Interspecies gene function prediction using semantic similarity.

Journal: BMC systems biology
Published Date: Dec 23, 2016

Abstract

BACKGROUND: Gene Ontology (GO) is a collaborative project that maintains and develops controlled vocabulary (or terms) to describe the molecular function, biological roles and cellular location of gene products in a hierarchical ontology. GO also provides GO annotations that associate genes with GO terms. GO consortium independently and collaboratively annotate terms to gene products, mainly from model organisms (or species) they are interested in. Due to experiment ethics, research interests of biologists and resources limitations, homologous genes from different species currently are annotated with different terms. These differences can be more attributed to incomplete annotations of genes than to functional difference between them.

Authors

  • Guoxian Yu
    College of Computer and Information Science, Southwest University, Chongqing 400715, China Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China.
  • Wei Luo
    Centre for Pattern Recognition and Data Analytics, School of Information Technology, Deakin University, Geelong, Victoria, Australia.
  • Guangyuan Fu
    College of Computer and Information Science, Southwest University, Chongqing 400715, China.
  • Jun Wang
    Department of Speech, Language, and Hearing Sciences and the Department of Neurology, The University of Texas at Austin, Austin, TX 78712, USA.

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