Classification of nervous system withdrawn and approved drugs with ToxPrint features via machine learning strategies.

Journal: Computer methods and programs in biomedicine
PMID:

Abstract

BACKGROUND AND OBJECTIVES: Early-phase virtual screening of candidate drug molecules plays a key role in pharmaceutical industry from data mining and machine learning to prevent adverse effects of the drugs. Computational classification methods can distinguish approved drugs from withdrawn ones. We focused on 6 data sets including maximum 110 approved and 110 withdrawn drugs for all and nervous system diseases to distinguish approved drugs from withdrawn ones.

Authors

  • Aytun Onay
    Department of Computer Engineering, TOBB University of Economics & Technology, 06560, Ankara, Turkey.
  • Melih Onay
    Department of Environmental Engineering, Computational & Experimental Biochemistry Lab, Yuzuncu Yil University, 65080, Van, Turkey. Electronic address: melihonay@yyu.edu.tr.
  • Osman Abul
    Department of Computer Engineering, TOBB University of Economics & Technology, 06560, Ankara, Turkey.