Analyzing interactions on combining multiple clinical guidelines.

Journal: Artificial intelligence in medicine
PMID:

Abstract

Accounting for patients with multiple health conditions is a complex task that requires analysing potential interactions among recommendations meant to address each condition. Although some approaches have been proposed to address this issue, important features still require more investigation, such as (re)usability and scalability. To this end, this paper presents an approach that relies on reusable rules for detecting interactions among recommendations coming from various guidelines. It extends a previously proposed knowledge representation model (TMR) to enhance the detection of interactions and it provides a systematic analysis of relevant interactions in the context of multimorbidity. The approach is evaluated in a case study on rehabilitation of breast cancer patients, developed in collaboration with experts. The results are considered promising to support the experts in this task.

Authors

  • Veruska Zamborlini
    Department of Computer Science, Vrije Universiteit Amsterdam, The Netherlands; Luxembourg Institute of Science and Technology - LIST, Luxembourg. Electronic address: v.carrettazamborlini@vu.nl.
  • Marcos Da Silveira
    Luxembourg Institute of Science and Technology, 29 Avenue John F. Kennedy, L-1855 Luxembourg, Luxembourg.
  • Cédric Pruski
    Luxembourg Institute of Science and Technology, 29 Avenue John F. Kennedy, L-1855 Luxembourg, Luxembourg.
  • Annette Ten Teije
    Department of Computer Science, Vrije Universiteit Amsterdam, The Netherlands.
  • Edwin Geleijn
    Department Rehabilitation Medicine, VU Univ. Medical Centre, Amsterdam, The Netherlands.
  • Marike van der Leeden
    Department Rehabilitation Medicine, VU Univ. Medical Centre, Amsterdam, The Netherlands; Amsterdam Rehabilitation Research Center - Reade, Amsterdam, The Netherlands.
  • Martijn Stuiver
    Department of Physiotherapy, Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, The Netherlands.
  • Frank van Harmelen
    Department of Computer Science, Vrije Universiteit Amsterdam, The Netherlands.