TIGERi: modeling and visualizing the responses to perturbation of a transcription factor network.
Journal:
BMC bioinformatics
PMID:
28617232
Abstract
BACKGROUND: Transcription factor (TF) networks play a key role in controlling the transfer of genetic information from gene to mRNA. Much progress has been made on understanding and reverse-engineering TF network topologies using a range of experimental and theoretical methodologies. Less work has focused on using these models to examine how TF networks respond to changes in the cellular environment.