Construction of mass spectra database and diagnosis algorithm for head and neck squamous cell carcinoma.

Journal: Oral oncology
Published Date: Dec 1, 2017

Abstract

OBJECTIVES: Intraoperative identification of tumor margins is essential to achieving complete tumor resection. However, the process of intraoperative pathological diagnosis involves cumbersome procedures, such as preparation of cryosections and microscopic examination, thus requiring more than 30 min. Moreover, intraoperative diagnoses made by examining cryosections are occasionally inconsistent with postoperative diagnoses made by examining paraffin-embedded sections because the former are of poorer quality. We sought to establish a more rapid accurate method of intraoperative assessment.

Authors

  • Kei Ashizawa
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan.
  • Kentaro Yoshimura
    Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan. kyoshimura@yamanashi.ac.jp.
  • Hisashi Johno
    Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.
  • Tomohiro Inoue
    Department of Human Pathology, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan.
  • Ryohei Katoh
    Department of Human Pathology, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan.
  • Satoshi Funayama
    Department of Radiology, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan.
  • Kaname Sakamoto
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan.
  • Sen Takeda
    Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan. stakeda@yamanashi.ac.jp.
  • Keisuke Masuyama
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan.
  • Tomokazu Matsuoka
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan. Electronic address: tmatsu@yamanashi.ac.jp.
  • Hiroki Ishii
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan. Electronic address: ishiih@yamanashi.ac.jp.

Keywords

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