Changes of plasma Rap1A levels in patients with in-stent restenosis after percutaneous coronary intervention and the underlying mechanisms.

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
PMID: 38432855

Abstract

OBJECTIVES: Percutaneous coronary intervention (PCI) is one of the most important treatments for coronary artery disease (CAD). However, in-stent restenosis (ISR) after PCI is a serious complication without effective measures for prevention and treatment. This study aims to investigate the Ras-related protein 1A (Rap1A) level in ISR patients and in the tumor necrosis factor-α (TNF-α)-induced inflammatory injury model of human umbilical vein endothelial cells (HUVECs), to explore the role of Rap1A in regulating TNF-α-induced inflammation in HUVECs and to provide a new potential target for ISR prevention and treatment.

Authors

  • Haodong Gao
    Department of Cardiology, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008. 493648067@qq.com.
  • Yuanyuan Kuang
    Department of Cardiology, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008.
  • Yubo Liu
    Department of Cardiology, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008.
  • Yinzhuang Zhang
    Department of Cardiology, First Hospital of Changsha, Changsha 410005, China.
  • Ping Wang
    School of Chemistry and Chemical Engineering, Shandong University of Technology, 255049, Zibo, PR China. Electronic address: wangping876@163.com.
  • Qilin Ma
    Department of Cardiology, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha 410008. mqilin2004@163.com.

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