AIMC Topic: Interleukin-6
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A genetic algorithm-based ensemble model for efficiently identifying interleukin 6 inducing peptides.
Scientific reports
Jul 1, 2025
Interleukin-6 (IL-6) is a cytokine with diverse biological activities that contribute to a variety of physiologic and immune responses. IL-6-inducing peptides are the short protein fragments that are critical for playing a contributing role in biolog...
Automated Electrical Detection of Proteins for Oral Squamous Cell Carcinoma in an Integrated Microfluidic Chip Using Multi-Frequency Impedance Cytometry and Machine Learning.
Sensors (Basel, Switzerland)
Mar 4, 2025
Proteins can act as suitable biomarkers for the prognosis and diagnosis of certain conditions and can help us gain an understanding of the fundamental processes that occur inside an organism. In this work, we present a fully automated machine learnin...
Neural Network-Enhanced Electrochemical/SERS Dual-Mode Microfluidic Platform for Accurate Detection of Interleukin-6 in Diabetic Wound Exudates.
Analytical chemistry
Feb 22, 2025
Interleukin-6 (IL-6) plays a pivotal role in the inflammatory response of diabetic wounds, providing critical insights for clinicians in the development of personalized treatment strategies. However, the low concentration of IL-6 in biological sample...
RAG_MCNNIL6: A Retrieval-Augmented Multi-Window Convolutional Network for Accurate Prediction of IL-6 Inducing Epitopes.
Journal of chemical information and modeling
Feb 19, 2025
Interleukin-6 (IL-6) is a critical cytokine involved in immune regulation, inflammation, and the pathogenesis of various diseases, including autoimmune disorders, cancer, and the cytokine storm associated with severe COVID-19. Identifying IL-6 induci...
Deep-Learning-Assisted Digital Fluorescence Immunoassay on Magnetic Beads for Ultrasensitive Determination of Protein Biomarkers.
Analytical chemistry
Jan 24, 2025
Digital fluorescence immunoassay (DFI) based on random dispersion magnetic beads (MBs) is one of the powerful methods for ultrasensitive determination of protein biomarkers. However, in the DFI, improving the limit of detection (LOD) is challenging s...
IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network.
Biomolecules
Jan 10, 2025
Interleukin-6 (IL-6) is a potent glycoprotein that plays a crucial role in regulating innate and adaptive immunity, as well as metabolism. The expression and release of IL-6 are closely correlated with the severity of various diseases. IL-6-inducing ...
Evaluation of the effect of cell freshness on pyrogen detection using a serum-free monocyte-activation test.
PloS one
Dec 30, 2024
Pyrogens cause shock symptoms when released into the bloodstream. They are classified into two main categories: endotoxins (lipopolysaccharides [LPS]) and non-endotoxin pyrogens. The monocyte activation test (MAT) is an in vitro assay to detect pyrog...
Association between serum endocan levels and organ failure in hospitalized patients with cirrhosis.
PloS one
Dec 26, 2024
BACKGROUND & AIMS: Acute-on-chronic liver failure is a syndrome characterized by organ failure and high short-term mortality. The lack of reliable biomarkers for the early detection of acute-on-chronic liver failure is a significant challenge. Endoth...
Blood Biomarker Signatures for Slow Gait Speed in Older Adults: An Explainable Machine Learning Approach.
Brain, behavior, and immunity
Dec 12, 2024
Maintaining physical function is crucial for independent living in older adults, with gait speed being a key predictor of health outcomes. Blood biomarkers may potentially monitor older adults' mobility, yet their association with slow gait speed sti...
Estrogen-mediated modulation of sterile inflammatory markers and baroreflex sensitivity in ovariectomized female Wistar rats.
Archives of endocrinology and metabolism
Nov 6, 2024
OBJECTIVE: This study aims to explore the role of estrogen in providing cardioprotective benefits to premenopausal women, examining how hormonal differences between sexes influence the prevalence of cardiovascular diseases (CVDs) in women.
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