Decoding diagnosis and lifetime consumption in alcohol dependence from grey-matter pattern information.

Journal: Acta psychiatrica Scandinavica
Published Date: Mar 1, 2018

Abstract

OBJECTIVE: We investigated the potential of computer-based models to decode diagnosis and lifetime consumption in alcohol dependence (AD) from grey-matter pattern information. As machine-learning approaches to psychiatric neuroimaging have recently come under scrutiny due to unclear generalization and the opacity of algorithms, our investigation aimed to address a number of methodological criticisms.

Authors

  • M Guggenmos
    Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • M Scheel
    Department of Radiology, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • M Sekutowicz
    Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • M Garbusow
    Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • M Sebold
    Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • C Sommer
    Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
  • K Charlet
    Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • A Beck
    Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • H-U Wittchen
    Institute for Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
  • U S Zimmermann
    Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
  • M N Smolka
    Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
  • A Heinz
    Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • P Sterzer
    Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • K Schmack
    Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.

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