Multicenter validation of [F]-FDG PET and support-vector machine discriminant analysis in automatically classifying patients with amyotrophic lateral sclerosis versus controls.

Journal: Amyotrophic lateral sclerosis & frontotemporal degeneration
Published Date: Jun 4, 2018

Abstract

OBJECTIVE: F-Fluorodeoxyglucose (F-FDG) positron emission tomography (PET) single-center studies using support vector machine (SVM) approach to differentiate amyotrophic lateral sclerosis (ALS) from controls have shown high overall accuracy on an individual patient basis using local a priori defined classifiers. The aim of the study was to validate the SVM accuracy on a multicentric level.

Authors

  • Ludovic D'hulst
    a Division of Nuclear Medicine and Department of Imaging and pathology , University Hospitals Leuven and KU Leuven , Leuven , Belgium.
  • Donatienne Van Weehaeghe
    a Division of Nuclear Medicine and Department of Imaging and pathology , University Hospitals Leuven and KU Leuven , Leuven , Belgium.
  • Adriano Chiò
    b ALS Center, 'Rita Levi Montalcini' Department of Neuroscience , University of Torino , Torino , Italy.
  • Andrea Calvo
    b ALS Center, 'Rita Levi Montalcini' Department of Neuroscience , University of Torino , Torino , Italy.
  • Cristina Moglia
    b ALS Center, 'Rita Levi Montalcini' Department of Neuroscience , University of Torino , Torino , Italy.
  • Antonio Canosa
    b ALS Center, 'Rita Levi Montalcini' Department of Neuroscience , University of Torino , Torino , Italy.
  • Angelina Cistaro
    d Positron Emission Tomography Center IRMET S.p.A , Turin , Italy.
  • Stefanie Ma Willekens
    a Division of Nuclear Medicine and Department of Imaging and pathology , University Hospitals Leuven and KU Leuven , Leuven , Belgium.
  • Joke De Vocht
    e Department of Neurology , University Hospitals Leuven and Laboratory of Neurobiology, Center for Brain & Disease Research KU Leuven and VIB , Leuven , Belgium.
  • Philip van Damme
    Department of Medical Informatics, Amsterdam Public Health research institute, Academic Medical Center, University of Amsterdam, The Netherlands. Electronic address: philip.vandamme@student.uva.nl.
  • Marco Pagani
    f Department of Nuclear Medicine , Karolinska Hospital , Stockholm , Sweden, and.
  • Koen Van Laere
    a Division of Nuclear Medicine and Department of Imaging and pathology , University Hospitals Leuven and KU Leuven , Leuven , Belgium.

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