Knowledge-Based Planning for Identifying High-Risk Stereotactic Ablative Radiation Therapy Treatment Plans for Lung Tumors Larger Than 5 cm.

Journal: International journal of radiation oncology, biology, physics
Published Date: Aug 14, 2018

Abstract

PURPOSE: Stereotactic ablative body radiation therapy (SABR) for lung tumors ≥5 cm can be associated with more toxicity than that for smaller tumors. We investigated the relationship between dosimetry and toxicity and used a knowledge-based planning solution to retrospectively perform individualized treatment plan quality assurance (QA) with the aim of identifying where planning could have been improved.

Authors

  • Saar Van't Hof
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan, Amsterdam, The Netherlands.
  • Alexander R Delaney
    Department of Radiotherapy, VU University Medical Center, Amsterdam, The Netherlands.
  • Hilâl Tekatli
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan, Amsterdam, The Netherlands.
  • Jos Twisk
    Department of Epidemiology and Biostatistics, VU University Medical Center, De Boelelaan, Amsterdam, The Netherlands.
  • Ben J Slotman
    Department of Radiotherapy, VU University Medical Center, Amsterdam, The Netherlands.
  • Suresh Senan
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan, Amsterdam, The Netherlands.
  • Max Dahele
    Department of Radiotherapy, VU University Medical Center, Amsterdam, The Netherlands.
  • Wilko F A R Verbakel
    Department of Radiotherapy, VU University Medical Center, Amsterdam, The Netherlands.

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