Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1.

Journal: British journal of pharmacology
PMID: 30270561

Abstract

BACKGROUND AND PURPOSE: Liquorice is the root of Glycyrrhiza glabra, which is a popular food in Europe and China that has previously shown benefits for skeletal fatigue and nutrient metabolism. However, the mechanism and active ingredients remain largely unclear. The aim of this study was to investigate the active ingredients of liquorice for muscle wasting and elucidate the underlying mechanisms.

Authors

  • Zeng-Yan Huang
    The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Ling-Jun Wang
    The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Jia-Jia Wang
    The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Wen-Jun Feng
    The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Zhong-Qi Yang
    The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Shi-Hao Ni
    The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Yu-Sheng Huang
    The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Huan Li
    National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
  • Yi Yang
    Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Ming-Qing Wang
    School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
  • Rong Hu
    College of Chemistry and Chemical Engineering, Yunnan Normal University , Yunnan, Kunming, 650092, People's Republic of China.
  • Heng Wan
    Department of Endocrinology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
  • Chan-Juan Wen
    Department of Radiology, Nan Fang Hospital of Southern Medical University, Guangzhou, China.
  • Shao-Xiang Xian
    The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Lu Lu
    China School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.

Keywords

External Resources

Popular Topics
Recent Journals