AIMC Topic: Glycyrrhiza

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Glabridin from L. Exhibits Anti-Triple-Negative Breast Cancer Effects by Regulating Various Cell Cycle Genes.

Journal of agricultural and food chemistry Sep 16, 2025
Glabridin (GLA), a characteristic polyphenolic extracted from the renowned sweet plant L., demonstrates potent anticancer effects. This study aims to investigate the effects of GLA on triple-negative breast cancer (TNBC) and its underlying mechanisms...
Antineoplastic Agents, Phytogenic Phenols Cell Proliferation Mice, Inbred BALB C Isoflavones Cell Cycle Proteins Glycyrrhiza Cell Cycle Cell Line, Tumor Mice Plant Extracts Triple Negative Breast Neoplasms Female Animals Humans
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Unraveling potent Glycyrrhiza glabra flavonoids as AKT1 inhibitors using network pharmacology and machine learning-assisted QSAR.

Molecular diversity May 8, 2025
Glycyrrhiza glabra (G. glabra) phytocompounds have been reported to interact with neurological targets, including those implicated in epilepsy, and may modulate epilepsy-related targets. While substantial evidence supports their potential antiepilept...
Flavonoids Proto-Oncogene Proteins c-akt Molecular Docking Simulation Protein Kinase Inhibitors Network Pharmacology Glycyrrhiza Quantitative Structure-Activity Relationship Humans Machine Learning
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Deep learning-based network pharmacology for exploring the mechanism of licorice for the treatment of COVID-19.

Scientific reports Apr 10, 2023
Licorice, a traditional Chinese medicine, has been widely used for the treatment of COVID-19, but all active compounds and corresponding targets are still not clear. Therefore, this study proposed a deep learning-based network pharmacology approach t...
Angiotensin-Converting Enzyme 2 Network Pharmacology Deep Learning Glycyrrhiza Molecular Docking Simulation COVID-19 SARS-CoV-2
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Analysis of Licorice () Root Extract Activity on in Comparison to Chlorhexidine and Fluoride Mouthwash.

The journal of contemporary dental practice Dec 1, 2019
AIM: The present study was done to determine the activity of licorice root extract on () in comparison to chlorhexidine and fluoride mouthwash.
Plant Extracts Streptococcus mutans Humans Chlorhexidine Dental Caries Mouthwashes Fluorides Glycyrrhiza
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Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1.

British journal of pharmacology Dec 4, 2018
BACKGROUND AND PURPOSE: Liquorice is the root of Glycyrrhiza glabra, which is a popular food in Europe and China that has previously shown benefits for skeletal fatigue and nutrient metabolism. However, the mechanism and active ingredients remain lar...
Structure-Activity Relationship Plant Roots Models, Molecular Machine Learning Molecular Structure Muscular Atrophy Animals Dose-Response Relationship, Drug Forkhead Box Protein O1 Glycyrrhiza Computational Biology Mice, Inbred C57BL Muscle, Skeletal Benzopyrans Plant Extracts Transcription, Genetic Male Mice
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