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Forkhead Box Protein O1

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Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1.

British journal of pharmacology 30270561
BACKGROUND AND PURPOSE: Liquorice is the root of Glycyrrhiza glabra, which is a popular food in Europe and China that has previously shown benefits for skeletal fatigue and nutrient metabolism. However, the mechanism and active ingredients remain lar...
Animals Benzopyrans Computational Biology Dose-Response Relationship, Drug Forkhead Box Protein O1 Glycyrrhiza Machine Learning Male Mice Mice, Inbred C57BL Models, Molecular Molecular Structure Muscle, Skeletal Muscular Atrophy Plant Extracts Plant Roots Structure-Activity Relationship Transcription, Genetic
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Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.

eLife 32406817
The transcriptional activation and repression during NK cell ontology are poorly understood. Here, using single-cell RNA-sequencing, we reveal a novel role for T-bet in suppressing the immature gene signature during murine NK cell development. Based ...
Animals Bone Marrow Cells Cluster Analysis Forkhead Box Protein O1 Gene Expression Profiling Gene Expression Regulation Genotype Killer Cells, Natural Machine Learning Mechanistic Target of Rapamycin Complex 2 Mice, Inbred C57BL Mice, Knockout Phenotype Proto-Oncogene Proteins c-akt Rapamycin-Insensitive Companion of mTOR Protein Regulatory-Associated Protein of mTOR RNA-Seq Single-Cell Analysis T-bet Transcription Factor T-Box Domain Proteins Transcriptome
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