Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation.

Journal: NeuroImage. Clinical
PMID: 30991616

Abstract

Adolescent binge drinking has been associated with higher risks for the development of many health problems throughout the lifespan. Adolescents undergo multiple changes that involve the co-development processes of brain, personality and behavior; therefore, certain behavior, such as alcohol consumption, can have disruptive effects on both brain development and personality maturation. However, these effects remain unclear due to the scarcity of longitudinal studies. In the current study, we used multivariate approaches to explore discriminative features in brain functional architecture, personality traits, and genetic variants in 19-year-old individuals (n = 212). Taking advantage of a longitudinal design, we selected features that were more drastically altered in drinkers with an earlier onset of binge drinking. With the selected features, we trained a hierarchical model of support vector machines using a training sample (n = 139). Using an independent sample (n = 73), we tested the model and achieved a classification accuracy of 71.2%. We demonstrated longitudinally that after the onset of binge drinking the developmental trajectory of improvement in impulsivity slowed down. This study identified the disrupting effects of adolescent binge drinking on the developmental trajectories of both brain and personality.

Authors

  • Hongtao Ruan
    School of Mathematical Sciences, Fudan University, Shanghai 200433, PR China; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, PR China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, PR China.
  • Yunyi Zhou
    School of Mathematical Sciences, Fudan University, Shanghai 200433, PR China; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, PR China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, PR China.
  • Qiang Luo
    Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, PR China; Department of Psychology and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, PR China. Electronic address: qluo@fudan.edu.cn.
  • Gabriel H Robert
    EA 4712 "Behavior and Basal Ganglia", Rennes University 1, Rennes, France.
  • Sylvane Desrivières
    Centre for Population Neuroscience and Stratified Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London SE5 8AF, United Kingdom.
  • Erin Burke Quinlan
    Kings College London, London, United Kingdom.
  • ZhaoWen Liu
    School of Computer Science and Technology, Xidian University, Xi'an 710071, Shannxi, PR China.
  • Tobias Banaschewski
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
  • Arun L W Bokde
    Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
  • Uli Bromberg
    University Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany.
  • Christian Büchel
    University Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany.
  • Herta Flor
    Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany.
  • Vincent Frouin
    NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.
  • Hugh Garavan
    Departments of Psychiatry and Psychology, University of Vermont, 05405 Burlington, VT, USA.
  • Penny Gowland
    Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
  • Andreas Heinz
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charitéplatz 1, Berlin, Germany.
  • Bernd Ittermann
    Physikalisch-Technische Bundesanstalt (PTB), Braunschweig, Abbestr. 2 - 12, Berlin, Germany.
  • Jean-Luc Martinot
    Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité; and Maison de Solenn, Paris, France.
  • Marie-Laure Paillère Martinot
    Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes; Sorbonne Université; and AP-HP, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.
  • Frauke Nees
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
  • Dimitri Papadopoulos Orfanos
    NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.
  • Luise Poustka
    Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075 Göttingen, Germany.
  • Sarah Hohmann
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
  • Juliane H Fröhner
    Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
  • Michael N Smolka
    Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
  • Henrik Walter
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, CCM, Berlin, German.
  • Robert Whelan
    School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland. robert.whelan@tcd.ie.
  • Fei Li
    Institute for Precision Medicine, Tsinghua University, Beijing, China.
  • Gunter Schumann
    Centre for Population Neuroscience and Stratified Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry Centre, King's College London, London SE5 8AF, United Kingdom.
  • Jianfeng Feng

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