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Adolescent Development

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Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development.

Drug metabolism and disposition: the biological fate of chemicals
It is generally acknowledged that there is a need and role for informative pharmacokinetic models to improve predictions and simulation as well as individualization of drug therapy in pediatric populations of different ages and developmental stages. ...

Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
OBJECTIVES: One of the major challenges facing psychiatry is how to incorporate biological measures in the classification of mental health disorders. Many of these disorders affect brain development and its connectivity. In this study, we propose a n...

Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation.

NeuroImage. Clinical
Adolescent binge drinking has been associated with higher risks for the development of many health problems throughout the lifespan. Adolescents undergo multiple changes that involve the co-development processes of brain, personality and behavior; th...

A comparison of fMRI and behavioral models for predicting inter-temporal choices.

NeuroImage
In an inter-temporal choice (IteCh) task, subjects are offered a smaller amount of money immediately or a larger amount at a later time point. Here, we are using trial-by-trial fMRI data from 363 recording sessions and machine learning in an attempt ...

Traditional and New Methods of Bone Age Assessment-An Overview.

Journal of clinical research in pediatric endocrinology
Bone age is one of biological indicators of maturity used in clinical practice and it is a very important parameter of a child’s assessment, especially in paediatric endocrinology. The most widely used method of bone age assessment is by performing a...

Predicting brain age with complex networks: From adolescence to adulthood.

NeuroImage
In recent years, several studies have demonstrated that machine learning and deep learning systems can be very useful to accurately predict brain age. In this work, we propose a novel approach based on complex networks using 1016 T1-weighted MRI brai...

Pruning recurrent neural networks replicates adolescent changes in working memory and reinforcement learning.

Proceedings of the National Academy of Sciences of the United States of America
Adolescent development is characterized by an improvement in multiple cognitive processes. While performance on cognitive operations improves during this period, the ability to learn new skills quickly, for example, a new language, decreases. During ...