Prediction of skin dose in low-kV intraoperative radiotherapy using machine learning models trained on results of in vivo dosimetry.

Journal: Medical physics
PMID: 30620412

Abstract

PURPOSE: The purpose of this study was to implement a machine learning model to predict skin dose from targeted intraoperative (TARGIT) treatment resulting in timely adoption of strategies to limit excessive skin dose.

Authors

  • Michele Avanzo
    Division of Medical Physics, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, PN, Italy.
  • Giovanni Pirrone
    Division of Medical Physics, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, PN, Italy.
  • Mario Mileto
    Department of Breast Surgery, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, PN, Italy.
  • Samuele Massarut
    Department of Breast Surgery, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, PN, Italy.
  • Joseph Stancanello
    Division of Medical Physics, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, PN, Italy.
  • Milad Baradaran-Ghahfarokhi
    Division of Medical Physics, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, PN, Italy.
  • Alexandra Rink
    Department of Radiation Physics, Princess Margaret Cancer Centre, ON, M5G 2M9, Canada.
  • Loredana Barresi
    Division of Medical Physics, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, PN, Italy.
  • Lorenzo Vinante
    Radiation Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, PN, Italy.
  • Erica Piccoli
    Department of Breast Surgery, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, PN, Italy.
  • Marco Trovo
    Department of Radiation Oncology, Udine General Hospital, 33100, Udine, UD, Italy.
  • Issam El Naqa
    Department of Machine Learning, Moffitt Cancer Center, Tampa, Florida.
  • Giovanna Sartor
    Division of Medical Physics, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081, Aviano, PN, Italy.

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