Brain Age in Early Stages of Bipolar Disorders or Schizophrenia.

Journal: Schizophrenia bulletin
Published Date: Jan 1, 2019

Abstract

BACKGROUND: The greater presence of neurodevelopmental antecedants may differentiate schizophrenia from bipolar disorders (BD). Machine learning/pattern recognition allows us to estimate the biological age of the brain from structural magnetic resonance imaging scans (MRI). The discrepancy between brain and chronological age could contribute to early detection and differentiation of BD and schizophrenia.

Authors

  • Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada (Hajek, Cooke, Alda); Prague Psychiatric Centre/ National Institute of Mental Health, Prague, Czech Republic (Hajek, Kopecek, Novak, Hoschl, Alda); Charles University, 3rd Faculty of Medicine, Prague, Czech Republic (Kopecek, Novak, Hoschl, Alda).
  • Katja Franke
    Structural Brain Mapping Group, Department of Neurology, Jena University Hospital, Jena, Germany.
  • Marian Kolenic
    National Institute of Mental Health, Klecany, Czech Republic.
  • Jana Capkova
    National Institute of Mental Health, Klecany, Czech Republic.
  • Martin Matejka
    National Institute of Mental Health, Klecany, Czech Republic.
  • Lukas Propper
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
  • Rudolf Uher
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
  • Pavla Stopkova
    National Institute of Mental Health, Klecany, Czech Republic.
  • Tomas Novak
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada (Hajek, Cooke, Alda); Prague Psychiatric Centre/ National Institute of Mental Health, Prague, Czech Republic (Hajek, Kopecek, Novak, Hoschl, Alda); Charles University, 3rd Faculty of Medicine, Prague, Czech Republic (Kopecek, Novak, Hoschl, Alda).
  • Tomas Paus
    Rotman Research Institute and Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada.
  • Miloslav Kopecek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada (Hajek, Cooke, Alda); Prague Psychiatric Centre/ National Institute of Mental Health, Prague, Czech Republic (Hajek, Kopecek, Novak, Hoschl, Alda); Charles University, 3rd Faculty of Medicine, Prague, Czech Republic (Kopecek, Novak, Hoschl, Alda).
  • Filip Španiel
    National Institute of Mental Health, Klecany, Czech Republic.
  • Martin Alda
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada (Hajek, Cooke, Alda); Prague Psychiatric Centre/ National Institute of Mental Health, Prague, Czech Republic (Hajek, Kopecek, Novak, Hoschl, Alda); Charles University, 3rd Faculty of Medicine, Prague, Czech Republic (Kopecek, Novak, Hoschl, Alda).

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