Predicting Ewing Sarcoma Treatment Outcome Using Infrared Spectroscopy and Machine Learning.

Journal: Molecules (Basel, Switzerland)
PMID: 30893786

Abstract

BACKGROUND: Improved outcome prediction is vital for the delivery of risk-adjusted, appropriate and effective care to paediatric patients with Ewing sarcoma-the second most common paediatric malignant bone tumour. Fourier transform infrared (FTIR) spectroscopy of tissues allows the bulk biochemical content of a biological sample to be probed and makes possible the study and diagnosis of disease.

Authors

  • Radosław Chaber
    Clinic of Paediatric Oncology and Haematology, Faculty of Medicine, University of Rzeszow, ul. Kopisto 2a, 35-310 Rzeszow, Poland. radoslaw.chaber@gmail.com.
  • Christopher J Arthur
    School of Chemistry, University of Bristol, Bristol BS8 1TS, UK. Chris.Arthur@bristol.ac.uk.
  • Kornelia Łach
    Clinic of Paediatric Oncology and Haematology, Faculty of Medicine, University of Rzeszow, ul. Kopisto 2a, 35-310 Rzeszow, Poland. kornelia_lach@wp.pl.
  • Anna Raciborska
    Department of Surgical Oncology for Children and Youth, Institute of Mother and Child, 01-211 Warsaw, Poland. anna.raciborska@hoga.pl.
  • Elżbieta Michalak
    Department of Pathology, Institute of Mother and Child, 01-211 Warsaw, Poland. elzbieta.michalak@gmail.com.
  • Katarzyna Bilska
    Department of Surgical Oncology for Children and Youth, Institute of Mother and Child, 01-211 Warsaw, Poland. katarzyna.bilska@gmail.com.
  • Katarzyna Drabko
    Department of Pediatric Hematology, Oncology and Bone Marrow Transplant, Medical University of Lublin, 20-081 Lublin, Poland. katarzynadrabko@umlub.pl.
  • Joanna Depciuch
    Institute of Nuclear Physics, Polish Academy of Sciences, 31-342 Krakow, Poland. joannadepciuch@gmail.com.
  • Ewa Kaznowska
    Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland. e.kaznowska@op.pl.
  • Józef Cebulski
    Center for Innovation and Transfer of Natural Sciences and Engineering Knowledge, University of Rzeszow, 35-959 Rzeszow, Poland. cebulski@ur.edu.pl.

Keywords

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