Prognostic Value of Deep Learning PET/CT-Based Radiomics: Potential Role for Future Individual Induction Chemotherapy in Advanced Nasopharyngeal Carcinoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
PMID:

Abstract

PURPOSE: We aimed to evaluate the value of deep learning on positron emission tomography with computed tomography (PET/CT)-based radiomics for individual induction chemotherapy (IC) in advanced nasopharyngeal carcinoma (NPC).

Authors

  • Hao Peng
    Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong, P. R. China.
  • Di Dong
    The Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
  • Meng-Jie Fang
    CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, P. R. China.
  • Lu Li
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, China.
  • Ling-Long Tang
    From the Department of Radiation Oncology (L.L., G.Q.Z., J.Y.L., L.L.T., S.M.H., J.M., Y.S.) and Imaging Diagnosis and Interventional Center (C.M.X.), Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, 651 Dongfeng Rd East, Guangzhou 510060, China; Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong SAR (Q.D., Y.M.J., P.A.H., H.C.); Imsight Medical Technology, Shenzhen, China (H.C.); Divisions of Radiation Oncology (J.T.S.W., M.L.K.C.) and Medical Sciences (M.L.K.C.), National Cancer Center Singapore, Singapore; Oncology Academic Programme, Duke-NUS Medical School, Singapore (M.L.K.C.); Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, China (Y.Q.T.); Department of Radiation Oncology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China (W.L.C.); Department of Radiation Oncology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China (B.A.S.); Department of Radiation Oncology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China (F.L.); Department of Radiation Oncology, Zhejiang Provincial Cancer Hospital, Key Laboratory of Radiation Oncology of Zhejiang Province, Hangzhou, China (C.J.T.); and Department of Radiation Oncology, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, China (N.J.).
  • Lei Chen
    Department of Chemistry, Stony Brook University Stony Brook NY USA.
  • Wen-Fei Li
    Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong, P. R. China.
  • Yan-Ping Mao
    Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong, P. R. China.
  • Wei Fan
    Department of Epidemiology, School of Public Health, Soochow University, Suzhou 215123, China.
  • Li-Zhi Liu
    Department of Imaging Diagnosis and Interventional Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, P. R. China.
  • Li Tian
    Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China. tianlixy3@csu.edu.cn.
  • Ai-Hua Lin
    Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, P. R. China.
  • Ying Sun
    CFAR and I2R, Agency for Science, Technology and Research, Singapore.
  • Jie Tian
    CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
  • Jun Ma
    State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.