Model-free prostate cancer segmentation from dynamic contrast-enhanced MRI with recurrent convolutional networks: A feasibility study.

Journal: Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Published Date:

Abstract

Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) is a method of temporal imaging that is commonly used to aid in prostate cancer (PCa) diagnosis and staging. Typically, machine learning models designed for the segmentation and detection of PCa will use an engineered scalar image called K to summarize the information in the DCE time-series images. This work proposes a new model that amalgamates the U-net and the convGRU neural network architectures for the purpose of interpreting DCE time-series in a temporal and spatial basis for segmenting PCa in MR images. Ultimately, experiments show that the proposed model using the DCE time-series images can outperform a baseline U-net segmentation model using K. However, when other types of scalar MR images are considered by the models, no significant advantage is observed for the proposed model.

Authors

  • Peter Q Lee
    Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada.
  • Alessandro Guida
    Biomedical Translational Imaging Centre, Nova Scotia Health Authority and IWK Health Centre, Halifax, NS, Canada.
  • Steve Patterson
    Nova Scotia Health Research Foundation, Halifax, NS, Canada.
  • Thomas Trappenberg
    Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Chris Bowen
    Biomedical Translational Imaging Centre, Nova Scotia Health Authority and IWK Health Centre, Halifax, NS, Canada; Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada.
  • Steven D Beyea
    Biomedical Translational Imaging Centre, Nova Scotia Health Authority and IWK Health Centre, Halifax, NS, Canada; Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada.
  • Jennifer Merrimen
    Department of Pathology, Dalhousie University, Halifax, NS, Canada.
  • Cheng Wang
    Department of Pathology, Dalhousie University, Halifax, NS, Canada.
  • Sharon E Clarke
    Biomedical Translational Imaging Centre, Nova Scotia Health Authority and IWK Health Centre, Halifax, NS, Canada; Department of Physics & Atmospheric Science, Dalhousie University, Halifax, NS, Canada; Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada. Electronic address: sharon.clarke@dal.ca.