Prediction of lithium response using clinical data.

Journal: Acta psychiatrica Scandinavica
PMID:

Abstract

OBJECTIVE: Promptly establishing maintenance therapy could reduce morbidity and mortality in patients with bipolar disorder. Using a machine learning approach, we sought to evaluate whether lithium responsiveness (LR) is predictable using clinical markers.

Authors

  • A Nunes
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
  • R Ardau
    Unit of Clinical Pharmacology, San Giovanni di Dio Hospital, University Hospital of Cagliari, Cagliari, Italy.
  • A Berghöfer
    Charité University Medical Center, Institute for Social Medicine, Epidemiology and Health Economics, Berlin, Germany.
  • A Bocchetta
    Unit of Clinical Pharmacology, San Giovanni di Dio Hospital, University Hospital of Cagliari, Cagliari, Italy.
  • C Chillotti
    Unit of Clinical Pharmacology, San Giovanni di Dio Hospital, University Hospital of Cagliari, Cagliari, Italy.
  • V Deiana
    Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
  • J Garnham
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
  • E Grof
    Mood Disorders Center of Ottawa, Ottawa, ON, Canada.
  • T Hajek
    3rd Faculty of Medicine,Charles University,Prague,Czech Republic.
  • M Manchia
    Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
  • B Müller-Oerlinghausen
    Charité Universitätsmedizin-Berlin, Berlin, Germany.
  • M Pinna
    Centro Lucio Bini, Cagliari e Roma, Italy.
  • C Pisanu
    Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
  • C O'Donovan
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
  • G Severino
    Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
  • C Slaney
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
  • A Suwalska
    Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
  • P Zvolsky
    Department of Psychiatry, Charles University, Prague, Czech Republic.
  • P Cervantes
    Department of Psychiatry, McGill University Health Centre, Montreal, QC, Canada.
  • M Del Zompo
    Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
  • P Grof
    Mood Disorders Center of Ottawa, Ottawa, ON, Canada.
  • J Rybakowski
    Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
  • L Tondo
    Centro Lucio Bini, Cagliari e Roma, Italy.
  • T Trappenberg
    Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada.
  • M Alda
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.