Disentangling brain functional network remodeling in corticobasal syndrome - A multimodal MRI study.

Journal: NeuroImage. Clinical
Published Date:

Abstract

OBJECTIVE: The clinical diagnosis of corticobasal syndrome (CBS) represents a challenge for physicians and reliable diagnostic imaging biomarkers would support the diagnostic work-up. We aimed to investigate the neural signatures of CBS using multimodal T1-weighted and resting-state functional magnetic resonance imaging (MRI).

Authors

  • Tommaso Ballarini
    Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany. Electronic address: tommaso@cbs.mpg.de.
  • Franziska Albrecht
    Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.
  • Karsten Mueller
    Max Planck Institute for Human Cognitive and Brain Sciences & Clinic for Cognitive Neurology, University Hospital Leipzig, Germany.
  • Robert Jech
    Department of Neurology, Charles University, First Faculty of Medicine, Prague, Czech Republic.
  • Janine Diehl-Schmid
    Clinic and Polyclinic for Psychiatry & Psychotherapy, Technical University Munich, Germany.
  • Klaus Fliessbach
    Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Bonn, Germany.
  • Jan Kassubek
    Department of Neurology, University of Ulm, Ulm, Germany. jan.kassubek@uni-ulm.de.
  • Martin Lauer
    Clinic for Psychiatry, Psychosomatic medicine and Psychotherapy, University Würzburg, Germany.
  • Klaus Fassbender
    Clinic and Polyclinic for Neurology, Saarland University Homburg, Germany.
  • Anja Schneider
    Clinic for Psychiatry and Psychotherapy, University of Goettingen, Germany.
  • Matthis Synofzik
    Department of Neurodegenerative Diseases, Centre for Neurology & Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Jens Wiltfang
    Department of Psychiatry and Psychotherapy (NH, HE, JW), University of Göttingen Medical Center, Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE) (JW), Göttingen, Germany; Neurosciences and Signaling Group (JW), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
  • Markus Otto
    Department of Neurology, University of Ulm, Germany.
  • Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences & Clinic for Cognitive Neurology, University of Leipzig, and German Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany.