Predicted Prognosis of Patients with Pancreatic Cancer by Machine Learning.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
PMID: 31992588

Abstract

PURPOSE: Pancreatic cancer remains a disease of high mortality despite advanced diagnostic techniques. Mucins (MUC) play crucial roles in carcinogenesis and tumor invasion in pancreatic cancers. MUC1 and MUC4 expression are related to the aggressive behavior of human neoplasms and a poor patient outcome. In contrast, MUC2 is a tumor suppressor, and we have previously reported that MUC2 is a favorable prognostic factor in pancreatic neoplasia. This study investigates whether the methylation status of three genes from postoperative tissue specimens from patients with pancreatic neoplasms could serve as a predictive biomarker for outcome after surgery.

Authors

  • Seiya Yokoyama
    Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  • Taiji Hamada
    Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  • Michiyo Higashi
    Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. east@m2.kufm.kagoshima-u.ac.jp.
  • Kei Matsuo
    Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  • Kosei Maemura
  • Hiroshi Kurahara
  • Michiko Horinouchi
    Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  • Tsubasa Hiraki
    Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  • Tomoyuki Sugimoto
    Graduate School of Science and Engineering (Science), Kagoshima University, Kagoshima, Japan.
  • Toshiaki Akahane
    Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  • Suguru Yonezawa
    Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
  • Marko Kornmann
    Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
  • Surinder K Batra
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA; The Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: sbatra@unmc.edu.
  • Michael A Hollingsworth
    Fred and Pamela Buffet Cancer Center, Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska.
  • Akihide Tanimoto
    Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Keywords

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