Same same but different: A Web-based deep learning application revealed classifying features for the histopathologic distinction of cortical malformations.

Journal: Epilepsia
PMID: 32080846

Abstract

OBJECTIVE: The microscopic review of hematoxylin-eosin-stained images of focal cortical dysplasia type IIb and cortical tuber of tuberous sclerosis complex remains challenging. Both entities are distinct subtypes of human malformations of cortical development that share histopathological features consisting of neuronal dyslamination with dysmorphic neurons and balloon cells. We trained a convolutional neural network (CNN) to classify both entities and visualize the results. Additionally, we propose a new Web-based deep learning application as proof of concept of how deep learning could enter the pathologic routine.

Authors

  • Joshua Kubach
    Institute of Neuropathology, University Hospitals, Erlangen, Germany.
  • Angelika Muhlebner-Fahrngruber
    Department of (Neuro)Pathology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
  • Figen Soylemezoglu
    Department of Pathology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Hajime Miyata
    Department of Neuropathology, Research Institute for Brain and Blood Vessels, Akita Cerebrospinal and Cardiovascular Center, Akita, Japan.
  • Pitt Niehusmann
    Department of Neurology/Pathology, Oslo University Hospital, Oslo, Norway.
  • Mrinalini Honavar
    Department of Anatomic Pathology, Pedro Hispano Hospital, Matosinhos, Portugal.
  • Fabio Rogerio
    Department of Pathology, State University of Campinas, Campinas, Brazil.
  • Se-Hoon Kim
    Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
  • Eleonora Aronica
    Department of (Neuro) Pathology, Academic Medical Center, Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
  • Rita Garbelli
    Epilepsy Unit, Milan, Italy.
  • Samuel Vilz
    Institute of Neuropathology, University Hospitals, Erlangen, Germany.
  • Alexander Popp
    Institute of Neuropathology, University Hospitals, Erlangen, Germany.
  • Stefan Walcher
    Institute of Neuropathology, University Hospitals, Erlangen, Germany.
  • Christoph Neuner
    Institute of Neuropathology, University Hospitals, Erlangen, Germany.
  • Michael Scholz
    Institute of Anatomy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Stefanie Kuerten
    Institute of Anatomy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Verena Schropp
    Institute of Anatomy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Sebastian Roeder
    Department of Neurology, University Hospitals Erlangen, Erlangen, Germany.
  • Philip Eichhorn
    Institute of Pathology, University Hospitals Erlangen, Erlangen, Germany.
  • Markus Eckstein
    Institute of Pathology, University Hospitals Erlangen, Erlangen, Germany.
  • Axel Brehmer
    Institute of Anatomy, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
  • Katja Kobow
    Institute of Neuropathology, University Hospitals, Erlangen, Germany.
  • Roland Coras
    Institute of Neuropathology, University Hospitals, Erlangen, Germany.
  • Ingmar Blumcke
    Institute of Neuropathology, University Hospitals, Erlangen, Germany.
  • Samir Jabari
    Institute of Neuropathology, University Hospitals, Erlangen, Germany.

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