Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies-PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice.

Journal: Schizophrenia bulletin
Published Date: Feb 26, 2020

Abstract

In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with the early stages of psychosis in the hope that these could aid the prediction of onset and clinical outcome. Despite advancements in the field, neuroimaging has yet to deliver. This is in part explained by the use of univariate analytical techniques, small samples and lack of statistical power, lack of external validation of potential biomarkers, and lack of integration of nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN is an international, longitudinal, multicenter study on the early stages of psychosis which uses machine learning techniques to analyze imaging, clinical, cognitive, and biological data with the aim of facilitating the prediction of psychosis onset and outcome. In this article, we provide an overview of the PSYSCAN protocol and we discuss benefits and methodological challenges of large multicenter studies that employ neuroimaging measures.

Authors

  • Stefania Tognin
    Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Hendrika H van Hell
    Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands.
  • Kate Merritt
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Inge Winter-van Rossum
    Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands.
  • Matthijs G Bossong
    Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands.
  • Matthew J Kempton
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Gemma Modinos
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Paolo Fusar-Poli
    Department of Psychosis Studies, The Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
  • Andrea Mechelli
    Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. Electronic address: a.mechelli@kcl.ac.uk.
  • Paola Dazzan
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.
  • Arija Maat
    Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands.
  • Lieuwe de Haan
    University of Amsterdam, Academic Medical Center, Department of Psychiatry, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands. Electronic address: l.dehaan@amc.uva.nl.
  • Benedicto Crespo-Facorro
    Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Madrid, Spain.
  • Birte Glenthøj
    Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
  • Stephen M Lawrie
    Division of Psychiatry, School of Clinical Sciences, University of Edinburgh, The Royal Edinburgh Hospital, Morningside Park, UK.
  • Colm McDonald
    Centre for Neuroimaging & Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland.
  • Oliver Gruber
    Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
  • Therese van Amelsvoort
    Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.
  • Celso Arango
  • Tilo Kircher
    Department of Psychiatry, University of Marburg, Marburg, Germany.
  • Barnaby Nelson
    Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia; The Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.
  • Silvana Galderisi
    Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Rodrigo Bressan
    Interdisciplinary Lab for Clinical Neurosciences (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil.
  • Jun S Kwon
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
  • Mark Weiser
    Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel.
  • Romina Mizrahi
    Institute of Medical Science, University of Toronto, Toronto, Canada.
  • Gabriele Sachs
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
  • Anke Maatz
    Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
  • René Kahn
    Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands.
  • Phillip McGuire
    Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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