Automating three-dimensional osteoarthritis histopathological grading of human osteochondral tissue using machine learning on contrast-enhanced micro-computed tomography.

Journal: Osteoarthritis and cartilage
Published Date:

Abstract

OBJECTIVE: To develop and validate a machine learning (ML) approach for automatic three-dimensional (3D) histopathological grading of osteochondral samples imaged with contrast-enhanced micro-computed tomography (CEμCT).

Authors

  • S J O Rytky
    Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland. Electronic address: santeri.rytky@oulu.fi.
  • A Tiulpin
    Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland; Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland. Electronic address: aleksei.tiulpin@oulu.fi.
  • T Frondelius
    Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland. Electronic address: juha.frondelius@student.oulu.fi.
  • M A J Finnilä
    Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland; Medical Research Center, University of Oulu, Oulu, Finland. Electronic address: mikko.finnila@oulu.fi.
  • S S Karhula
    Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland; Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland. Electronic address: sakari.karhula@oulu.fi.
  • J Leino
    Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland. Electronic address: janina.leino@student.oulu.fi.
  • K P H Pritzker
    Department of Laboratory Medicine and Pathobiology, Surgery University of Toronto, Toronto, Ontario, Canada; Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address: kenpritzker@gmail.com.
  • M Valkealahti
    Department of Surgery and Intensive Care, Oulu University Hospital, Oulu, Finland. Electronic address: maarit.valkealahti@oulu.fi.
  • P Lehenkari
    Medical Research Center, University of Oulu, Oulu, Finland; Department of Surgery and Intensive Care, Oulu University Hospital, Oulu, Finland; Cancer and Translational Medical Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland. Electronic address: petri.lehenkari@oulu.fi.
  • A Joukainen
    Department of Orthopaedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland. Electronic address: antti.joukainen@kuh.fi.
  • H Kröger
    Department of Orthopaedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland. Electronic address: heikki.kroger@kuh.fi.
  • H J Nieminen
    Dept. of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland; Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland. Electronic address: heikki.j.nieminen@aalto.fi.
  • S Saarakkala
    Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland; Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland. Electronic address: simo.saarakkala@oulu.fi.