Prediction of response to anti-vascular endothelial growth factor treatment in diabetic macular oedema using an optical coherence tomography-based machine learning method.

Journal: Acta ophthalmologica
PMID:

Abstract

PURPOSE: To predict the anti-vascular endothelial growth factor (VEGF) therapeutic response of diabetic macular oedema (DME) patients from optical coherence tomography (OCT) at the initiation stage of treatment using a machine learning-based self-explainable system.

Authors

  • Jing Cao
    Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, People's Republic of China.
  • Kun You
    Merchant Marine College, Shanghai Maritime University, Shanghai 201306, China; Mechanical and Electrical Engineering, Yantai Gold College, Shandong 265400, China.
  • Kai Jin
    Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Lixia Lou
    Department of Ophthalmology, College of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Yao Wang
    Department of Gastrointestinal Surgery, Zhongshan People's Hospital, Zhongshan, Guangdong, China.
  • Menglu Chen
    Department of Ophthalmology, College of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Xiangji Pan
    Department of Ophthalmology, The Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.
  • Ji Shao
    Department of Ophthalmology, College of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Zhaoan Su
    Department of Ophthalmology, The Second Affiliated Hospital of Zhejiang University, College of Medicine, Hangzhou, 310009, China.
  • Jian Wu
    Department of Medical Technology, Jiangxi Medical College, Shangrao, Jiangxi, China.
  • Juan Ye
    Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.