Radiogenomics for predicting p53 status, PD-L1 expression, and prognosis with machine learning in pancreatic cancer.

Journal: British journal of cancer
Published Date: Oct 1, 2020

Abstract

BACKGROUND: Radiogenomics is an emerging field that integrates "Radiomics" and "Genomics". In the current study, we aimed to predict the genetic information of pancreatic tumours in a simple, inexpensive, and non-invasive manner, using cancer imaging analysis and radiogenomics. We focused on p53 mutations, which are highly implicated in pancreatic ductal adenocarcinoma (PDAC), and PD-L1, a biomarker for immune checkpoint inhibitor-based therapies.

Authors

  • Yosuke Iwatate
    Division of Hepato-Biliary-Pancreatic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan.
  • Isamu Hoshino
  • Hajime Yokota
    Department of Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Fumitaka Ishige
    Division of Hepato-Biliary-Pancreatic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan.
  • Makiko Itami
    Division of Clinical Pathology, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan.
  • Yasukuni Mori
    Department of Applied and Cognitive Informatics, Graduate School of Engineering, Chiba University, Chiba, Japan.
  • Satoshi Chiba
    Division of Hepato-Biliary-Pancreatic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan.
  • Hidehito Arimitsu
    Division of Hepato-Biliary-Pancreatic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan.
  • Hiroo Yanagibashi
    Division of Hepato-Biliary-Pancreatic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan.
  • Hiroki Nagase
    Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba, 260-8717, Japan.
  • Wataru Takayama
    Division of Hepato-Biliary-Pancreatic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan.

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