AI-driven quantification, staging and outcome prediction of COVID-19 pneumonia.

Journal: Medical image analysis
Published Date: Oct 15, 2020

Abstract

Coronavirus disease 2019 (COVID-19) emerged in 2019 and disseminated around the world rapidly. Computed tomography (CT) imaging has been proven to be an important tool for screening, disease quantification and staging. The latter is of extreme importance for organizational anticipation (availability of intensive care unit beds, patient management planning) as well as to accelerate drug development through rapid, reproducible and quantified assessment of treatment response. Even if currently there are no specific guidelines for the staging of the patients, CT together with some clinical and biological biomarkers are used. In this study, we collected a multi-center cohort and we investigated the use of medical imaging and artificial intelligence for disease quantification, staging and outcome prediction. Our approach relies on automatic deep learning-based disease quantification using an ensemble of architectures, and a data-driven consensus for the staging and outcome prediction of the patients fusing imaging biomarkers with clinical and biological attributes. Highly promising results on multiple external/independent evaluation cohorts as well as comparisons with expert human readers demonstrate the potentials of our approach.

Authors

  • Guillaume Chassagnon
    Department of Radiology, Hopital Cochin, APHP, 75014 Paris, France; Université Paris Cité, 75006 Paris, France.
  • Maria Vakalopoulou
    Ecole CentraleSupelec, 91190, Gif-sur-Yvette, France.
  • Enzo Battistella
    U1030 Molecular Radiotherapy, Paris-Sud University - Gustave Roussy - Inserm - Paris-Saclay University, Villejuif, France; Department of Medical Physics, Gustave Roussy - Paris-Saclay University, Villejuif, France; MICS Laboratory, CentraleSupélec, Paris-Saclay University, Gif-sur-Yvette, France.
  • Stergios Christodoulidis
  • Trieu-Nghi Hoang-Thi
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Séverine Dangeard
    Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).
  • Eric Deutsch
    Gustave Roussy Cancer Campus, Villejuif, France.
  • Fabrice Andre
    Université Paris-Saclay, Institut Gustave Roussy, Inserm U981 Predictive Biomarkers and New Therapeutic Strategies in Oncology, 114 Rue Edouard Vaillant, Villejuif 94800, France; Université Paris-Saclay, Institut Gustave Roussy, Prism Precision Medicine Center, 114 Rue Edouard Vaillant, Villejuif 94800, France.
  • Enora Guillo
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Nara Halm
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Stefany El Hajj
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Florian Bompard
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Sophie Neveu
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Chahinez Hani
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Ines Saab
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Aliénor Campredon
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Hasmik Koulakian
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Souhail Bennani
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Gael Freche
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Maxime Barat
    Radiology Department, Hopital Cochin - AP-HP. Centre Université de Paris, 27 Rue du Faubourg Saint-Jacques, Paris 75014, France; Université de Paris, 85 boulevard Saint-Germain, Paris 75006, France.
  • Aurelien Lombard
    TheraPanacea, 29 Rue du Faubourg Saint-Jacques, Paris 75014, France.
  • Laure Fournier
    PARCC UMRS 970, INSERM, Paris, France; Université Paris Cité, AP-HP, Hopital européen Georges Pompidou, Paris, France.
  • Hippolyte Monnier
    Radiology Department, Hopital Européen Georges Pompidou - AP-HP.Centre Université de Paris, 20 Rue Université Paris-Saclay, Paris 75015, France.
  • Téodor Grand
    Radiology Department, Hopital Européen Georges Pompidou - AP-HP.Centre Université de Paris, 20 Rue Université Paris-Saclay, Paris 75015, France.
  • Jules Gregory
    Department of Radiology, Beaujon Hospital, Paris Nord Val de Seine Hospitals, APHP, Clichy, France and Université de Paris, INSERM U1153, Epidemiology and Biostatistics Research Center (CRESS), Methods of Therapeutic Evaluation of Chronic Diseases (METHODS) Team, Paris, France.
  • Yann Nguyen
    AP-HP, GHU Pitié-Salpêtrière, DMU ChIR, Service ORL, GRC Robotique et Innovation Chirurgicale, Sorbonne Université, Paris, France. yann.nguyen@inserm.fr.
  • Antoine Khalil
    Department of Radiology, APHP Nord, Hôpital Bichat, 75018 Paris, France.
  • Elyas Mahdjoub
    Université de Paris, 85 boulevard Saint-Germain, Paris 75006, France; Radiology Department, Hopital Bichat - AP-HP.Nord Université de Paris, 46 Rue Henri Huchard, Paris 75018, France.
  • Pierre-Yves Brillet
    Department of Radiology, Hôpital Avicenne, Paris 13 University, 93000 Bobigny, France.
  • Stéphane Tran Ba
    Radiology Department, Hopital Avicenne - AP-HP.Hopitaux universitaires Paris Seine-Saint-Denis, 125 Rue de Stalingrad, Bobigny 93000, France; Université Sorbonne Paris Nord, 99 Avenue Jean Baptiste Clément, Villetaneuse 93430, France.
  • Valérie Bousson
    Université de Paris, 85 boulevard Saint-Germain, Paris 75006, France; Radiology Department, Hopital Lariboisiére - AP-HP.Nord Université de Paris, 2 Rue Ambroise Paré, Paris 75010, France.
  • Ahmed Mekki
    Department of Radiology, Gustave Roussy Cancer Campus, Villejuif, France; Université Paris-Saclay, Paris, France; Department of Neuroradiology, C.H.U Bicêtre AP-HP, Le Kremlin-Bicêtre, France. Electronic address: ahmekki@gmail.com.
  • Robert-Yves Carlier
    Radiology Department, Hopital Ambroise Paré - AP-HP.Université Paris Saclay, 9 Avenue Charles de Gaulle, Boulogne-Billancourt 92100 France; Radiology Department, Raymond-Pointcaré - AP-HP.Université Paris Saclay, 104 Boulevard Raymond Poincaré, Garches 92380, France; Université Paris-Saclay, Espace Technologique Bat. Discovery - RD 128 - 2e ét, Saint-Aubin 91190, France.
  • Marie-Pierre Revel
    Department of Radiology (G.C., S.D., M.P.R.) and Respiratory Medicine and National Cystic Reference Center (P.R.B.), Groupe Hospitalier Cochin-Hotel Dieu, AP-HP, Université Paris Descartes, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, France; Center for Visual Computing, Ecole CentraleSupelec, Grande Voie des Vignes, Chatenay Malabry, France (G.C., E.I.Z., N.P.); U1016 Inserm, Institut Cochin, Paris, France (G.C., P.R.B., C.M., M.P.R.); Radiology Department (S.B.) and Pulmonary Department (R.C.), Hôpital Arnaud de Villeneuve, CHU de Montpellier, Université de Montpellier, Montpellier, France; ERN-Lung CF Network, France (P.R.B., C.M.); and TheraPanacea, Paris-Biotech-Santé, Paris, France (N.P.).
  • Nikos Paragios
    TheraPanacea, Paris, France.

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