A peripheral inflammatory signature discriminates bipolar from unipolar depression: A machine learning approach.
Journal:
Progress in neuro-psychopharmacology & biological psychiatry
PMID:
33045321
Abstract
BACKGROUND: Mood disorders (major depressive disorder, MDD, and bipolar disorder, BD) are considered leading causes of life-long disability worldwide, where high rates of no response to treatment or relapse and delays in receiving a proper diagnosis (~60% of depressed BD patients are initially misdiagnosed as MDD) contribute to a growing personal and socio-economic burden. The immune system may represent a new target to develop novel diagnostic and therapeutic procedures but reliable biomarkers still need to be found.