Phytochemical, antibacterial, antioxidant and cytoxicity investigation of .

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences
PMID: 34218550

Abstract

The phytochemical investigation of led to the isolation of 18 known compounds of which were four flavones, three anthraquinones, one phenyl propanoic derivative, five triterpenoids, four steroids and a mixture of glucose. Luteolin () and soranjidiol () were allylated and/or prenylated to give four new semisynthesized derivatives which were fully characterized as 7,3',4'--triallylluteolin (), luteolin-7,3',4'--triprenyls (), luteolin-5,7,3',4'--tetraprenyls () and 6--allylsoranjidiol (). Their structures were established using spectroscopic analysis including 1D, 2D NMR and MS data. The cytotoxic, antioxidant and antimicrobial activities of extracts, fractions, isolated compounds and semi-synthesized derivatives were evaluated. The petroleum ether and EtOAc extracts exhibited good cytotoxic potency on KB-3-1 cell line with IC of >0.1 and 0.025 mg/mL respectively, while compounds and were the most active (IC > 0.0001 M). Compounds and showed the best antioxidant activities (45.5 and 55.8 µM); while compounds and showed the best antibacterial activities with MICs values ranges from 8.55 to 132 µM.

Authors

  • Jean Francois Zeutsop
    Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
  • Raymond Ngansop Nono
    Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
  • Marcel Frese
    Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501Bielefeld, Germany.
  • Jean Rodolphe Chouna
    Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
  • Bruno Ndjakou Lenta
    Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon.
  • Pépin Nkeng-Efouet-Alango
    Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
  • Norbert Sewald
    Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, P.O. Box 100131, 33501Bielefeld, Germany.

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