AIMC Topic: Biphenyl Compounds

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Design and Synthesis of Magnolol Derivatives Using Integrated CNNs and Pharmacophore Approaches for Enhanced Parasiticidal Activity in Aquaculture.

Journal of agricultural and food chemistry
Aquaculture is a rapidly growing sector of global food production, playing a vital role in poverty alleviation, food security, and income generation. However, it faces substantial challenges, particularly due to infections caused by the protozoan , l...

Deep eutectic solvent-based green extraction of Strychnos potatorum seed phenolics: Process optimization via response surface methodology and artificial neural network.

Talanta
The current research focused on extraction optimization of bioactive compounds from Strychnos potatorum seeds (SPs) using an eco-friendly glycerol-sodium acetate based deep eutectic solvent (DES). The optimization was accomplished using response surf...

Artificial Intelligence Assisted Ultrasonic Extraction of Total Flavonoids from .

Molecules (Basel, Switzerland)
Flavonoids in were studied. The flavonoids in were extracted by ultrasonic method, and the extraction conditions were modeled and optimized by response the surface methodology and the artificial intelligence method. The results show that the ultras...

Machine Learning Prediction of Allosteric Drug Activity from Molecular Dynamics.

The journal of physical chemistry letters
Allosteric drugs have been attracting increasing interest over the past few years. In this context, it is common practice to use high-throughput screening for the discovery of non-natural allosteric drugs. While the discovery stage is supported by a ...

Phytochemical, antibacterial, antioxidant and cytoxicity investigation of .

Zeitschrift fur Naturforschung. C, Journal of biosciences
The phytochemical investigation of led to the isolation of 18 known compounds of which were four flavones, three anthraquinones, one phenyl propanoic derivative, five triterpenoids, four steroids and a mixture of glucose. Luteolin () and soranjidiol...

The role of sacubitril/valsartan in the treatment of chronic heart failure with reduced ejection fraction in hypertensive patients with comorbidities: From clinical trials to real-world settings.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
BACKGROUND: Sacubitril/valsartan, the first agent to be approved in a new class of drugs called angiotensin receptor neprilysin inhibitors (ARNIs), has been shown to reduce cardiovascular mortality and morbidity compared to enalapril in outpatient su...

Machine Learning Algorithms for Liquid Crystal-Based Sensors.

ACS sensors
We present a machine learning (ML) framework to optimize the specificity and speed of liquid crystal (LC)-based chemical sensors. Specifically, we demonstrate that ML techniques can uncover valuable feature information from surface-driven LC orientat...

Extraction, identification and structure-activity relationship of antioxidant peptides from sesame (Sesamum indicum L.) protein hydrolysate.

Food research international (Ottawa, Ont.)
To elucidate the sequence, origin and structure-activity relationship of antioxidant peptides from sesame protein, sesame protein was hydrolysed by a dual-enzyme system comprised alcalase and trypsin, then this hydrolysate was fractionated by ultrafi...

Exploring the phenolic profile, antioxidant, antidiabetic and anti-hemolytic potential of Prunus avium vegetal parts.

Food research international (Ottawa, Ont.)
The aim of the present work was to evaluate the phenolic profile of leaves, stems and flowers of P. avium and their biological potential. For this purpose, two extracts of each matrix (hydroethanolic and infusion) were prepared. A total of twenty-six...

Characterization of Polyphenolic Content in the Aquatic Plants Ruppia cirrhosa and Ruppia maritima -A Source of Nutritional Natural Products.

Molecules (Basel, Switzerland)
Herein, the polyphenolic content in extracts of (Petagna) Grande and L.was fully characterized for the first time. High amounts of the main compound chicoric acid () (≤30.2 ± 4.3 mg/g) were found in both species. In addition, eight flavonoids, nam...