Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR*D and CAN-BIND-1.

Journal: PloS one
PMID: 34181661

Abstract

OBJECTIVES: Antidepressants are first-line treatments for major depressive disorder (MDD), but 40-60% of patients will not respond, hence, predicting response would be a major clinical advance. Machine learning algorithms hold promise to predict treatment outcomes based on clinical symptoms and episode features. We sought to independently replicate recent machine learning methodology predicting antidepressant outcomes using the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) dataset, and then externally validate these methods to train models using data from the Canadian Biomarker Integration Network in Depression (CAN-BIND-1) dataset.

Authors

  • John-Jose Nunez
    Department of Psychiatry, University of British Columbia, Vancouver, Canada.
  • Teyden T Nguyen
    Department of Computer Science, University of British Columbia, Vancouver, Canada.
  • Yihan Zhou
    Department of Computer Science, University of British Columbia, Vancouver, Canada.
  • Bo Cao
    Department of Psychiatry, University of Alberta, Edmonton, Canada.
  • Raymond T Ng
    PROOF Centre of Excellence, Vancouver, BC, Canada.
  • Jun Chen
    Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Benicio N Frey
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
  • Roumen Milev
    Department of Psychiatry and Psychology, Queen's University, Providence Care Hospital, Kingston, ON, Canada.
  • Daniel J Müller
    Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, ON, Canada.
  • Susan Rotzinger
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
  • Claudio N Soares
    Department of Psychiatry, Queen's University School of Medicine, Kingston, ON, Canada.
  • Rudolf Uher
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
  • Sidney H Kennedy
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
  • Raymond W Lam
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

Keywords

External Resources

Popular Topics
Recent Journals