The rostral anterior cingulate cortex (rACC) has been identified as a key region in treatment-resistant depression (TRD), potentially influencing the adaptive interplay between the default mode network and other critical neural networks. This study a...
Depression is a significant public health issue, consistently ranking among the leading causes of mortality, reduced quality of life, and economic burden. Despite available treatments, approximately one-third of patients exhibit resistance to standar...
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Jul 11, 2025
Despite advances in the treatment of major depressive disorder (MDD) yet a substantial proportion of patients fail to achieve remission and instead develop treatment-resistant depression (TRD). Identifying robust clinical predictors of response is es...
Difficult-to-treat depression (DTD) has been proposed as a broader and more clinically comprehensive perspective on a person's depressive disorder where, despite treatment, they continue to experience significant burden. We sought to develop a tool c...
Identifying predictors of treatment response to repetitive transcranial magnetic stimulation (rTMS) remain elusive in treatment-resistant depression (TRD). Leveraging electronic medical records (EMR), this retrospective cohort study applied supervise...
Although there are many treatment options available for depression, a large portion of patients with depression are diagnosed with treatment-resistant depression (TRD), which is characterized by an inadequate response to antidepressant treatment. Id...
OBJECTIVES: Antidepressants are first-line treatments for major depressive disorder (MDD), but 40-60% of patients will not respond, hence, predicting response would be a major clinical advance. Machine learning algorithms hold promise to predict trea...
BACKGROUND: About one third of patients treated with antidepressant do not show sufficient symptoms relief and up to 15% of patients remain symptomatic even after multiple trials are applied, configuring a state called treatment resistant depression ...
BACKGROUND: Current antidepressants have shown certain limitations in the treatment of unipolar depression. Their long onset of action, interactions, and side effects are obstacles to achieving lasting remission of this prevalent, often chronic or re...
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depression disorder (MDD), particularly for treatment-resistant cases. However, identifying translatable biomarkers predictive of treatment outcomes re...
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